Signalling by VEGF receptors

Contents

1. VEGF receptors and their ligands
   
   
2. The chorioallantoic membrane (CAM) angiogenesis assay
   
   
3. Structure and function of VEGF family ligands and their receptors
   
   
4. General mechanism of dimerization of receptor tyrosine kinases
   
   
5. Determining receptor activity by FRET
   
   
6. Signaling pathways activated by VEGF receptors
   
   
7. Signaling pathways activated by VEGF receptors
   
   
8. Activation of VEGFR-2 leads to receptor phosphorylation at tyrosine residues
   
   
9. How is cooperation among VEGF receptors regulated?
   
   
10. Effect of VEGF on cell-cell communication through GAP junctions
    
    
11. Effect of VEGF-A on gap junctional communication of endothelial Eahy.926 cells
    
    
12. GAP junctions form channels between cells
    
    
13. Disruption of GAP junctions by VEGF depends on Src and MAP kinase activity
    
    
14. Disruption of GJC by various VEGF family members
    
    
15. Phosphorylation of Cx43 by VEGF
    
    
16. VEGF does not promote disassembly of GAPJs but disruption of GAPJ permeability
    
    
17. Ligand promotes dimerization of the VEGFR extracellular domain
    
    
18. Model for activation of receptor tyrosine kinases; VEGF receptors
    
    
19. The VEGFR-2 co-receptor Neuropilin-1 is required for vessel sprouting in an embryoid body angiogenesis assay
    
    
20. Enhanced branching of vessels in matrigel plugs by a gain of function mutant, VEGF-A-NZ2 binding VEGFR-2 and NRP-1
    
    

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Last updated:
Januar 30, 2009 (Freitag)