In 1974 I finished my studies in the department of Chemistry at
the University of Basel with a diploma. I moved to the department of Biochemistry
at the Biozentrum in Basel to Prof. Max M. Burger's laboratory to start my Ph.D.
thesis on 'Growth regulation of cells in culture with a modified, non-toxic
lectin (succinylated Concanavalin A)'. This work was continued as a post-doctoral
fellow after finishing the doctorate with a degree in biochemistry
in 1978. In 1981 I moved to the laboratory of Prof. T. Benjamin
at Harvard Medical School in Boston as a research fellow. I was funded
by fellowships from Swiss National Foundation followed by an appointment as instructor at Harvard Medical School. I investigated the role of
Polyomavirus middle
tumor antigen in the process of cell transformation. In 1984 I returned
to the Biozentrum in Basel as a research fellow where I continued my work on Polyomavirus. In 1987 I obtained a position at the
Friedrich Miescher-Institute in Basel as an independent research fellow and became an associate group leader in 1989
and continued to study cell
transformation and signal transduction by Polyomavirus middle-T, in particular
the mechanisms responsible for complex formation between middle-T and Src family
tyrosine kinases. In
April 1997 I moved to the Paul Scherrer Institut (PSI) where we investigate signalling by vascular
endothelial growth factors (VEGF). In a second, related project, we developed
reagents for targeting tumor cells based on VEGF and its receptors and on tumor
vasculature-specific marker molecules. In January 2003
our research group was renamed to 'Molecular Cell Biology' (MCB) and is
now part
of the 'Laboratory of Biomolecular Research' at PSI.
In 1991 I started a teaching program in
'Molecular Virology' and in 1993 my habilitation at the science faculty of the
University of Basel was accepted. In 2001 I was promoted to 'Titularprofessor in
Biochemistry' at the Biozentrum of the University of Basel. I now teach 'Molecular Virology' and 'Cellular Signalling'
in the Aufbaustufe program of the Biozentrum at the University of Basel.
My
hobbies are music and reading and outdoor activities such as biking, skiing and
hiking in the mountains. |